Cabinet Professeur Dr Jean-Pierre Hachem

Je vous invite à découvrir notre Centre laser au Luxembourg, située à l'entrée de Esch-sur-Alzette, à 12 minutes de Luxembourg ville. Equipé avec les dernières technologies, nous vous offrons des services allant de la dermatologie classique et le traitement des maladies cutanées jusqu'aux procédures lasers les plus complexes: épilation au laser, traitement de la couperose, des tattoos, lifting du visage et du corps, rajeunissement, cryolipolyse etc.
Nous proposons aussi des soins esthétiques tels que l'injection de la toxine botulique (Botox, Azzalure, Xeomine), l'acide hyaluronique et la transplantation de cheveux.

Diplômes

• dermatologue

Publications

• Shwachman-Diamond syndrome presenting with early ichthyosis
• associated dermal and epidermal intracellular lipid droplets
• hypoglycemia
• d later distinctive clinical SDS phentoype. Scalais E
• et al.Am J Med Genet A. 2016
• Caspase-14-deficient mice are more prone to the developement of parakeratosis. Hoste E et al. J Invest Dermatol. 2013
• Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeabilitiy barrier status and differentiation. Roelandt T et al.Exp Dermtol 2012
• Infant epidermal skin physiology: adaption after birth. Randomized controlle trial. Fluhr JW
• et al. Br J Dermatol. 2012
• Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Gruber R
• et al. Am J Pathol. 2011
• Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation. Roelandt T
• et al. J Dermatol Sci. 2011
• Functional skin adaption in infancy - almost complete but not fully competent. Fluhr JW
• et al. Exp Dermatol 2010
• Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. Hachem JP
• et al. Invest Dermatol 2010
• LEKTI-1 in sickness and in health. Roelandt T
• et al.Int J Cosmet Sci. 2009
• pH-regulated mechanisms account for pigment-type differences in epidermal barrier function. Gunathilake R
• et al. J Invest Dermatol. 2009
• The "caveolae brake hypthesis" and the epidermal barrier. Roelandt T
• et al. J Invest Dermatol. 2008
• Clinical scoring and biophysical evaluation of nasolabial skin barrier damage caused by rhinorrhea. De Paepe K
• et al. J Invest Dermatol 2009
• Seasonal effects on the nasolabial skin condition. De Paepe K
• et al. Skin Pharacol Physiol. 2009
• Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification. Fluhr JW et al J Invest Dermatol. 2009
• Proteolytically active allergens cause barrier breakdown. Roelandt T
• et al. J Invest Dermatol. 2008
• Epidermal ceramidase activity regulates epidermal desquamation via stratum corneum acidification. Houben E
• et al. Skin Pharmacol Physiol. 2008
• Novel mutation in the human hairless gene once more erroneously diagnosed and treated as "alopecia areata". Roelandt T
• et al. Br J Dermatol. 2008
• Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Dermerjian M
• et al. Am J Pathol. 2008
• LEKTI fragments secifically inhibit KLK5
• KLK7 and KLK14 and control desquamation through a pH-dependent interaction. Deraision C
• et al. Mol Biol Cell. 2007
• Caspase-14 protects against epidermal UVB photodamage and water loss. denecker G
• et al. Nat Cell Biol. 2007
• Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline. Alirezai M
• et al. Eur J Dermatol. 2007
• The two compartment model of the stratum corneum: biochemical aspects and pathophysiological implications. Hachem JP
• et al. Verh. K Acad Geneeskd Bel. 2006
• Serine protease signaling of epideral permeability barrier homeostasis. hachem JP
• et al J Invest Dermatol. 2006
• Extracellular pH Controls NHE1 expression in epidermis and keratinocytes: implications for barrier repair. Hachem JP
• et al. J Invest Dermatol. 2005
• Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. Hachem P
• et al. J Invest Dermatol. 2005
• Parotid secretory protein is an HDL-associated protein with anticandidal acitvity. Khovidhunkit W
• et al. Am J Physiol Regul Integr Comp Physiol. 2005
• The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Darsow U
• et al. Allergy .2004
• Functional consequences of a neutral pH in neonatal rat stratum corneum. Fluhr JW et al. J Invest Dermatol. 2004
• Functional consequesnces of a neutral pH in neonatal rat stratum corneum. Fluhr JW
• et al. J Invest Dermatol. 2004
• Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis). Schmuth M
• et al. Invst Dermatol. 2004
• Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. Elias PM
• et al J Invest Dermatol. 2004
• Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? A comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%
• versus lymecycline plus gel vehicle. Cunliffe WJ
• et al. J Am Acad Dermatol. 2003
• pH directly regulates epidermal permeability barrier homeostasis
• and stratum corneum integrity/cohesion. Hachem JP
• et al J Invest Dermatol 2003
• Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synsthesis accounts for functional abnormalities. Kao JS
• et al. J Invest Dermatol. 2003
• Role of peroxisome profliferator-acitvated receptor alpha in eidermal development in utero. Schmuth M
• et al. J Invest Dermatol. 2003
• Effect of rice starch as a bath additive on the barrier function on healthy but SLS-damaged skin an skin of atopic patients. De Paepe K
• et al. Acta Derm Venereol. 2002
• Evaluation of biophysical and clinical parameter of skin barrier function among hospital workers. Hachem JP
• et al. Contact Dermatitis. 2002
• Efficacy of topical corticosteroids in nickel-induced contact allergy. Hachem JP
• et al. Clin Exp Dermatol. 2002
• The effect of two moisturisers on skin barrier damage in allergic contact dermatitis. Hache JP
• et al Eur J Dermatol 2002
• Squamometry as a screening method for the evaluation of hydrating products. De Paepe K
• et al. Skin Res Technol. 2001
• Combination therapy improves the recovery of the skin barrier function: an experimental model using a contact allergy patch test comined with TEWL mesurements. Hachem JP
• et al. Dermatology. 2001
• Benefical effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. De Paepe K
• et al. Contact Dermatitis. 2001

Prix et récompenses

• Fullbright Award 2000 03/01 . - Commission for Educationa Exchange uSA Belgium
• Horlait-Dapsens Prize 2001 . 11/01 . - Horlait-Dapsens Brussels
• ESDR travel grant . 05/03 - IID
• Miami
• Krediet voor Studienverblijf 12/03 - FWO Vlaanderen
• Krediet voor Studienverblijf 12/04 . - FWO Vlaanderen
• Krediet voor Studienverblijf . 01/07 . - FWO Vlaanderen
• Fundamenteel Klinisch Maandaat 10/06 - FWO Vlaanderen
• Young Research Prize 2000 10/00 . - Roche Brussels
• Poster Prize 10/02 - 11th EADV congress Prague
• Fundamental Reseach Prize . 12/03 - Roche Brussels
• Fondation René Touraine-short exchange award 12/03 . - Fondation René Touraine - Hopital Saint Louis
• France
• Uriage Poster Prize 11/04 . - 13th EADV congress Prague
• Best paper prize 11/05 - la Roche-Posay foundation
• Pfizer Prize 01/05 - Pfizer Belgium
• Karel Lodewijk Verleysen Prijs 01/06 - Koninklijke Academie voor Geneesekunde